Omar Abdel-Wahab

Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.

Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell transcriptomic profiling of freshly isolated BM samples, combined with histologi...

Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms

The cellular landscape of druggable RNA-binding proteins.

PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia.

Findings demonstrate that PTBP1 supports AML proliferation by fine-tuning the expression and splicing of AML-essential genes, providing a workflow for systematically annotating RNA-associated protein dependencies in cancer.

Targeting EZH2 Oncogenic Splicing: Decoding the Regulatory Network and Antisense Correction

This study instigated a gene-specific targeted strategy by unlocking the regulatory network, and designed antisense oligonucleotides (ASOs) targeting important regulatory sites, demonstrating that ASO pharmacology is an actionable strategy for clinical development, challenging the existing paradigms in SF-mutated cance...