Amir Sharafkhaneh

Future horizons: Toward an integrated neuroscience of sleep.

Neural mechanisms and architecture of sleep.

Sleep, attention, and executive function in health and disease.

Sleep, emotional regulation, and limbic-cortical dynamics: From basic mechanisms to clinical translation.

Sleep, circadian rhythms, chronobiology, and neural synchrony: Integrative mechanisms in brain function, health, and disease.

This review explores how chronobiology and neuroscience intersect at the level of specific biological mechanisms, highlighting the suprachiasmatic nucleus as the central pacemaker, clock gene feedback loops as timekeepers, and thalamocortical circuits as mediators of neural synchrony.

Sleep, anxiety, and depression: The bidirectional brain-behavior axis.

This chapter explores how sleep, anxiety, and depression interact from various scientific and clinical viewpoints, including circadian rhythms, stress hormones, immune signalling, genetic and environmental effects, cognitive impairments, developmental factors, and new treatment options.

REM sleep behavior disorder and synucleinopathies.

This chapter discusses how RBD provides a window for testing neuroprotective and disease-modifying therapies that may delay or prevent overt synucleinopathy and reviews current symptom management approaches that mix pharmacological treatment with non-pharmacological safety measures for injury prevention and neuromodula...