REM sleep behavior disorder and synucleinopathies.

Prevalence of Probable REM Sleep Behavior Disorder in Essential Tremor

It is suggested that sleep-related symptoms may be relevant in ET and support further study with polysomnographic confirmation of RBD and longitudinal follow-up of these symptoms in ET patients.

Nigro-striatal deficits capture phenoconversion risk in isolated REM sleep behavior disorder

It is demonstrated that phenoconversion in iRBD relates similarly to dopaminergic denervation of the putamen and cell loss in the SN, which opens possibilities for using NM-MRI, which can simultaneously capture dopaminergic and noradrenergic deficits, as an alternative to nuclear imaging techniques when estimating phen...

What can narcolepsy teach us about hypocretin and dementia?

Sleep and circadian disturbances are associated with cognitive decline and dementia. Narcolepsy type 1 (NT1), characterized by severe sleep-wake disruption and loss of hypocretin, would therefore be expected to predispose individuals to premature brain aging. Yet available biomarker and neuroimaging findings do not con...

REM Sleep Disengagement of β Oscillations Permits Rapid Dream Movements in Parkinsonism

REM sleep behavior disorder is a hallmark of prodromal α-synucleinopathies, yet why patients with Parkinson’s disease can generate rapid, coordinated movements during REM sleep despite daytime bradykinesia remains unknown. Here we combined recordings of eye movements, cortical electroencephalography, and basal ganglia-...

The orexinergic system in Alzheimer's disease: from sleep disruption to accelerated neurodegeneration.

Sleep–neuroinflammation interactions in Alzheimer’s disease: a systematic review of biomarker pathways

The available evidence supports a biologically plausible, potentially bidirectional relationship between sleep disruption and AD pathology, while highlighting important gaps in translation.