Genetically proxied circulating metabolites showed reproducible associations with MDD, while reverse effects were supported by only two metabolic traits, which may help prioritization of candidate biomarkers for risk stratification in patient cohorts and generate hypotheses for mechanistic research.
Jian-Bin Du, Ancha Baranova, Hong-Bao Cao et al.· European Archives of Psychia...· 0 citations
Circulating lipid signaling molecules such as AEA and PEA may represent potential peripheral biomarkers of MDD, although longitudinal and mechanistic studies are needed to clarify the influence of treatment and comorbidities.
Muhammad Yaseen, Wei-Jen Chen, Jane-Pei-Chen Chang et al.· Brain, behavior, and immunit...· 1 citation
Genetic evidence linking inflammatory proteins to MS pathogenesis was uncovered, offering clues for novel therapeutic targets for this condition and strengthening the biological plausibility of inflammation-driven disease mechanisms.
Run-Yang Xu, Ancha Baranova, Hong-Bao Cao et al.· Current Neurovascular Resear...· 0 citations
Genetic evidence suggesting medication-specific associations between antidepressant use liability and T2D susceptibility is provided, highlighting that the metabolic effects of individual antidepressants may vary, thus, warranting further studies to determine the clinical relevance of the findings.
Dongming Liu, Ancha Baranova, Chenxin Xu et al.· European Archives of Psychia...· 0 citations
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