Association between antidepressant use and the risk of type 2 diabetes: a multi-stage Mendelian randomization study.

Causal Association Between Antidepressant Use and Thyroid Disease Risk: A Two-Sample Mendelian Randomization Study

Genetic evidence of potential associations between antidepressant use and increased risks of Hashimoto's thyroiditis and hypothyroidism is provided, and support consideration of thyroidfunction monitoring in patients receiving antidepressant treatment, particularly those with pre-existing thyroid risk factors.

Genetic evidence for a causal role of depression in late-onset Alzheimer disease: A Mendelian randomization study

Genetic evidence supporting a causal role for depression in the etiology of late-onset AD is provided, a link not observed for other major psychiatric disorders tested and highlighted the specific importance of managing depression as a potential strategy for mitigating AD risk.

Exploring the impacts of type 2 diabetes and metformin use on Parkinson’s disease: Mendelian randomization analysis and a national cohort study

Causal effects of diabetes and alcohol intake on Dupuytren's disease: a two-sample Mendelian randomization study in UK Biobank and FinnGen.

This MR study supported diabetes liability and higher alcohol intake as causal risk factors for DD, whereas genetically proxied obesity and smoking traits showed no clear causal effects, suggesting that better glycemic management and lower alcohol exposure may help reduce the risk of DD.

Evaluating the causal effects of circulating metabolites on major depression disorder.

Genetically proxied circulating metabolites showed reproducible associations with MDD, while reverse effects were supported by only two metabolic traits, which may help prioritization of candidate biomarkers for risk stratification in patient cohorts and generate hypotheses for mechanistic research.

Mendelian randomization analysis of the causal relationship between allergic rhinitis and depression and underlying mediation mechanisms

In MVMR, loneliness showed the strongest positive conditional association with depression, and sleep duration and anxiety remain plausible but unconfirmed candidate pathways, while the MVMR findings prioritize loneliness for further validation.