Scarless SARS-CoV-2 Genome Engineering and Variant Analysis
A genome engineering technology is used to change a single amino acid in the viruses’ main protease enzyme to match that of circulating Omicron isolates to demonstrate antiviral efficacy of approved drugs and uncover mutants with reduced drug sensitivity.
Agnieszka Dabrowska, Ashley Cuell, Rahul Basu et al.
· bioRxiv · 0 citations