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Author

Asmaa Saleh

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Oct 2026

Elucidating the Therapeutic Mechanisms of Nickel(II)– Hydroazinecarbothioamide Complexes Across Cancer, Microbial, and Oxidative Stress Models

Isatin‐based ligands have been recognized for their remarkable pharmacological potential and this study reports the synthesis, characterization, and biological evaluation of three novel nickel(II)‐isatin hydrazone complexes ( C1–C3 ). The complexes were characterized by FT‐IR, UV–vis, mass spectroscopy, DFT, magn...

Asmaa Saleh, Hend A. A. Ezelarab, H. M. Selim et al. · 0 citations
Aug 2026

New Tetrazole-1,3,4-Oxadiazole and 1,2,4-Triazole-based Benzothiazole Hybrids: Synthesis, Anticancer Activity, and Computational Investigations

Abstract Cancer is the most complex disease and safety of current drugs represents serious challenge to develop safer medications. Novel hybrids of sugar–benzothiazole–tetrazole–hydrazones, their derived 1,3,4-oxadiazoles and the 1,2,4-triazole glycoside were synthesized to study their anticancer potential with mechani...

Asmaa F. Kassem, Lama A. Alshabani, Asmaa Saleh et al. · 0 citations
Open access Aug 2026

Development of new imidazopyridine-based chalcones hybrids as potent antidiabetic and antioxidant agents: synthesis, in silico and in vitro evaluation

A novel series of six imidazopyridine-based chalcone hybrids is synthesized and evaluated their in vitro biological activities, including total antioxidant capacity, iron-reducing power, and radical scavenging (DPPH, ABTS, NO), as well as antidiabetic potential against α-amylase, α-glucosidase, and aldose reductase.

Hanan Abdelmawgoud Atia, Aladdin M. Srour, Hanaa Farag et al. · 0 citations
Aug 2026

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

In silico ADME profiling demonstrated promising pharmacokinetic behavior, characterized by robust gastrointestinal absorption and excellent predicted blood–brain barrier penetration, supporting the potential of these derivatives as promising multifunctional candidates for the development of anti‐Alzheimer agents.

Aisha A. Alsfouk, Riham A. El-Shiekh, Benson M Kariuki et al. · 0 citations
Open access Aug 2026

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies

The combined biochemical, cellular, and computational findings support the proposed involvement of the EGFR/PI3K/mTOR signaling pathway in its antiproliferative activity and identify DNA gyrase as a potential antibacterial target.

Hagar S. El-Hema, Esraa M. Adel, W. El-Dougdoug et al. · 0 citations

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