Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

Aisha A. Alsfouk Riham A. El-Shiekh Benson M Kariuki Eman Sabry Mohamed G. Abouelenein Asmaa Saleh Mahmoud G. A. Saleh Aladdin M. Srour

Aug 2026 · Drug development research (Print) · Vol 87 · 0 citations · 41 references

Medicine

TL;DR

In silico ADME profiling demonstrated promising pharmacokinetic behavior, characterized by robust gastrointestinal absorption and excellent predicted blood–brain barrier penetration, supporting the potential of these derivatives as promising multifunctional candidates for the development of anti‐Alzheimer agents.

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