Author

Riham A. El-Shiekh

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Review Open access Aug 2026

Aucubin as a multifunctional iridoid glycoside: Molecular pharmacology and therapeutic mechanisms supporting its potential as a drug discovery scaffold.

This review positions aucubin as a biologically informative iridoid glycoside with substantial scaffold-level relevance for future natural-product-inspired therapeutic development, rather than as a near-term clinical drug candidate.

M. Arafat, Mostafa K. Mohammad, Kareem A. Attallah et al. · European Journal of Pharmaco... · 0 citations

Review Open access Aug 2026

Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral disturbance, largely associated with amyloid-β accumulation, tau protein pathology, synaptic dysfunction, oxidative stress and neuroinflammation. Previous research emphasizes the critical...

A. Shaheen, Mou-Sa A. Mai, Merhan O. Hindam et al. · Frontiers in Pharmacology · 2 citations

Aug 2026

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

In silico ADME profiling demonstrated promising pharmacokinetic behavior, characterized by robust gastrointestinal absorption and excellent predicted blood–brain barrier penetration, supporting the potential of these derivatives as promising multifunctional candidates for the development of anti‐Alzheimer agents.

Aisha A. Alsfouk, Riham A. El-Shiekh, Benson M Kariuki et al. · Drug development research (P... · 0 citations

Open access Jul 2026

LC-QTOF-MS metabolic profiling and anti-MRSA activity of Asparagus officinalis L. spear methanolic extract in a skin infection mouse model

The findings obtained here demonstrate the potential of A. officinalis L. spears for pharmaceutical, agricultural, and food industry applications and demonstrates significant in vitro inhibition of the biofilm formation and enhanced biofilm detachment against MRSA.

Passent M. Abdel-Baki, Mariam Hassan, Noha A. Ahmed et al. · RSC Advances · 0 citations