Author

Mohamed G. Abouelenein

Lecturer of Organic chemistry, Faculty of Science, Menoufia University

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Open access Oct 2026

Indole-1,2,4-triazole mannich hybrids as dual anti-newcastle disease virus genotype VII D and antimicrobial agents: In ovo efficacy and computational profiling

Newcastle disease virus (NDV) remains a major threat to global poultry production, particularly when viral outbreaks are aggravated by secondary microbial infections. To address this challenge, a focused series of indole–1,2,4-triazole Mannich hybrids (4a–d, 5c–d, 6a–d, 7a–d, and 8a–b) was designed and synthesized as p...

Mohamed G. Abouelenein, Yasmin K. Elsersy, H. Abd-Alla et al. · Scientific Reports · 0 citations

Aug 2026

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

In silico ADME profiling demonstrated promising pharmacokinetic behavior, characterized by robust gastrointestinal absorption and excellent predicted blood–brain barrier penetration, supporting the potential of these derivatives as promising multifunctional candidates for the development of anti‐Alzheimer agents.

Aisha A. Alsfouk, Riham A. El-Shiekh, Benson M Kariuki et al. · Drug development research (P... · 0 citations