Author

Aziz ur Rehman Aziz

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Review Open access Sep 2026

Toward trustworthy virtual cells: a roadmap for perturbation-resolved, context-aware, and experimentally validated cell models

Single-cell perturbation technologies, multimodal omics, spatial profiling, and generative modeling are transforming the virtual cell from a theoretical concept into a practical objective for cell biology. Yet current efforts often emphasize model scale, data volume, or predictive breadth, while the trustworthiness req...

Wang-Shu Li, Aziz ur Rehman Aziz, Bo-Wen Xu et al. · Frontiers in Cell and Develo... · 0 citations

Review Open access Sep 2026

Circulating and tumor-infiltrating immune cell profiles in cervical cancer checkpoint blockade: multi-omics biomarkers of response and resistance

A blood-to-tumor framework is proposed in which dynamic peripheral phenotypes may monitor systemic immune competence, while tissue multi-omics may identify local immune exclusion, terminal exhaustion, and myeloid suppression.

Wang-Shu Li, Xiao-Hui Yu, Wen-Juan Wei et al. · Frontiers in Immunology · 0 citations