Author

B. Crespo-Facorro

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Sep 2026

Pleiotropic genetic architecture linking schizophrenia and substance use disorders

Findings suggest that part of SCZ liability reflects genetic susceptibility to SUDs with potential implications for patient stratification and clinical management.

S. Aranda, D. Koller, S. Papiol et al. · medRxiv · 0 citations

Open access Aug 2026

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.

P. B. Leung, K. C. Wong, S. Smart et al. · medRxiv · 0 citations