Author

Brittany N. Dugger

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Open access Sep 2026

Regional distribution of mineralized blood vessels in Alzheimer disease and clinicopathological associations: A multicenter autopsy study.

Mineralized blood vessels (MBV) are a form of vascular pathology associated with cerebrovascular aging and neurodegeneration; however, their regional distribution and clinicopathological correlates in Alzheimer disease (AD) remain poorly characterized. We examined 265 decedents with intermediate/high AD neuropathologic...

David Garcia, Naomi Saito, Shyam Tamizharasu et al. · Neurobiology of Aging · 0 citations

#explainable ai Review Sep 2026

Varenicline as a Repurposable Drug Candidate for ADRD Prevention

Objective: Effective strategies to prevent Alzheimer's disease and related dementias (ADRD) are limited. Implementing our Medication-Wide Association Study (MWAS+), we highlighted varenicline as a candidate. This study evaluated the association between varenicline use and risk of ADRD relative to nicotine replacement t...

P. Ma, J. Zhou, Y. Cheng et al. · medRxiv · 0 citations

#protein folding Open access Aug 2026

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

A scalable, open-source, deep-learning approach to quantify NFT burden in digital whole slide images (WSIs) of post-mortem human brain tissue and openly releases this multi-institution deep-learning pipeline to provide detailed NFT spatial distribution and morphology analysis capability at a scale otherwise infeasible...

S. Ghandian, Liane Albarghouthi, Kiana Nava et al. · Scientific Reports · 0 citations