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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Bang-Ce Ye

h-index 13 View on Semantic Scholar

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Oct 2026

An Integrated DNA Origami-Based RNA Degrader for Targeted Degradation of Oncogenic Mutant KRAS mRNA

Targeting mutant KRAS represents a critical yet unmet therapeutic challenge across multiple malignancies, as the structural diversity of oncogenic variants and absence of druggable pockets have impeded the development of effective small-molecule inhibitors. Here, we report an integrated RNA degrader system constructe...

Ying-Fu Li, Qing Huang, Pin-Ru Chen et al. · 0 citations
#protein folding Sep 2026

Engineering a Transcription Activation Toolkit by Rewiring Prokaryotic Transcription Factors and Synthetic Yeast Promoters in Yarrowia lipolytica

Yarrowia lipolytica is a promising industrial host, yet its metabolic engineering potential remains limited by insufficient genetic tools. Here, we engineered a synthetic Transcription Activation Toolkit (TAT) based on LacI–VPRH, a chimeric protein fusing the prokaryotic DNA-binding domain LacI with the eukaryotic ac...

Yunhe Li, Wen-Ping Wei, Ping Zhang et al. · 0 citations

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