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Non-motor symptom profiles differ among these dementia subtypes even at early stages, suggesting their potential utility as early disease-specific indicators.
A serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synthetic UU-rich RNA probes provides a proof-of-concept platform for the direct functional measurement of probe-competent TDP-43 species in serum.
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
This large mega-analysis of brain structural morphometrics derived from T1-weighed MRI scans from fifteen international research groups suggests subtle morphometric differences, particularly in prefrontal and motor regions, may represent predisposing vulnerabilities, compensatory mechanisms, or FND-specific alterations...
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