Transcription factor EB (TFEB) is a promising target for autophagy regulation and cancer therapy, yet it has long been regarded as an undruggable protein. Starting from eltrombopag, an FDA-approved agent that exhibits both thrombopoietin receptor (Tpo-R) agonistic activity and TFEB inhibitory potency, we performed syst...
Chang-Le Du, Ya-Ping Rong, Zi-Lu Wang et al.· Journal of Medicinal Chemist...· 0 citations
Biological assays demonstrate that the synthetic glucorhamnans effectively induce the release of tumor necrosis factor-α and the secretion of interleukin-6 and interleukin-12 in bone marrow-derived dendritic cells (BMDCs) in bone marrow-derived dendritic cells (BMDCs).
Hao-Tian Li, Peng Xu, Tao Yang et al.· Angewandte Chemie· 0 citations
The immunogenicity limitation has underscored the critical need for human vaccine adjuvants that can elicit potent and durable humoral and cellular immunity tailored to semisynthetic glycoconjugates. To circumvent the toxicity of Freund's adjuvant (FA) and advance a broad-spectrum, oligomannuronic acid-based semisynthe...
Xiao-Tong Wang, Xiang Ji, Hai-Yue Zheng et al.· Vaccine· 0 citations
A structure dynamics-based design strategy is reported that transforms OB into a selective antibacterial agent through rational modification of the nitrophenyl moiety, and establishes a 'kinetic sensor' strategy for achieving species selectivity.
