Bowen Li

Editing cells in place: Targeted in vivo gene editing of hematopoietic stem cells.

Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing.

Lipid Nanoparticles Based Multi-Scale Systemic Immune Programming for Cancer Therapy.

The clinical reach of cancer immunotherapy is currently limited by off-target toxicity, physical barriers in solid tumors, and the complex manufacturing of personalized cell therapies. This review presents multi-scale systemic immune programming as a transformative approach, in which lipid nanoparticles (LNPs) function...

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.

This work combined site-specific chemical modification of sup-tRNAs with cargo-tailored pulmonary lipid nanoparticle (LNP) engineering to overcome barriers and restore cystic fibrosis transmembrane conductance regulator (CFTR) expression and function.

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

This study provides direct evidence that VEXAS-specific TE govern HSC clonal dominance, thereby uncovering a regulatory axis underlying HSC biology and disease mechanisms, opening a therapeutic strategy directed towards the repetitive genome.