Author

Bobby Thomas

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#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia.

Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavi...

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · Proceedings of the National... · 0 citations

Review Open access Sep 2026

TLDc proteins: Stress-responsive nexus regulators of redox signaling, V-ATPase dynamics, and organellar crosstalk in neurodegeneration

This review integrates recent insights into how TLDc proteins coordinate organellar pH regulation and iron homeostasis and discusses how disruption of these interconnected pathways contributes to age-related neurodegeneration.

Mohammad Sajid Ghufran, Priyanka Soni, Bobby Thomas · Redox Biology · 0 citations