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BACKGROUND Methotrexate (MTX) is a cornerstone disease-modifying antirheumatic drug for rheumatoid arthritis (RA); however, it may attenuate vaccine-induced immune responses. Temporary MTX interruption around vaccination has been proposed to improve immunogenicity, but concerns remain regarding disease flare and safety...
MAO possesses considerable anti‐arthritic properties by downregulating pro‐inflammatory biomarkers such as IL‐1β, NF‐κB, IL‐6, TNF‐α, IL‐6, and NF‐κB and pro‐inflammatory biomarkers such as TNF‐α, IL‐1β, IL‐6, and NF‐κB were significantly downregulated in the arthritic control group.
The results demonstrate the cutting-edge potential of CRISPR/Cas9 multiplex approaches as next-generation methods for designing sustainable resistance to multifaceted plant virus diseases and contribute to understanding of CRISPR-based antiviral response mechanisms.
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