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Open access Aug 2026

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories relate to one another. Defining the temporal sequence of p...

J. D. De Houwer, Wenjie Kang, Renee van Buuren et al. · 0 citations
Open access Jul 2026

Machine-learning MRI stratification of genetic frontotemporal dementia for clinical trial enrichment

Machine-learning stratification of genetic FTD reveals a progressive and a dissociated disease track and provides individualized progression scores that closely track clinical status, enabling smaller, more efficient prevention and early-intervention trials than conventional MRI or NfL markers alone.

M. Soltaninejad, Y. Iturria-Medina, A. Bouzigues et al. · 0 citations

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