Author

C. Cenciarelli

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Review Open access Aug 2026

Investigating the role of costimulatory domains in enhancing CAR-T cell persistence in TNBC.

This work summarizes how costimulatory domains can mediate the persistence, function, and therapeutic potential of CAR-T cells in triple-negative breast cancer (TNBC), a highly aggressive malignancy with limited treatment options and an immunosuppressive tumor microenvironment. Although CAR-T cell therapy has produced...

Hany E. Marei, G. Pozzoli, C. Cenciarelli · Cancer Gene Therapy · 0 citations

#gene editing Review Open access Sep 2026

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

This review synthesizes recent advances in molecular engineering strategies that enhance CAR-T cell function beyond conventional receptor design and discusses how receptor engineering, genome editing, transcriptional and epigenetic regulation, metabolic reprogramming, synthetic gene circuits, and safety-control platfor...

Hany E. Marei, G. Pozzoli, S. Caratelli et al. · Stem cell research & therape... · 0 citations