Author

C. Dings

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Open access Nov 2026

Parent-metabolite PBPK model of methotrexate to inform pediatric extrapolation, transporter-mediated drug–drug interactions, and renal impairment

Methotrexate (MTX) is widely used in treating chronic inflammatory diseases and in chemotherapy for both adult and pediatric patients. Its pharmacokinetics are complex, as MTX is a substrate of multiple transporters. Particularly during high-dose chemotherapeutic use, it is associated with severe toxicities including r...

C. Dette, F. Marok, Veronika Alberg et al. · Scientific Reports · 0 citations

#protein folding Open access Oct 2026

Physiologically based pharmacokinetic modeling as a translational tool in forensic toxicology: from pig to human synthetic cannabinoid toxicokinetics using 5F-Cumyl-P7AICA and its major metabolite as a case study.

A PBTK model was developed for 5FC and its primary metabolite N-pentanoic acid in pigs and translated to humans for predicting systemic and tissue-specific exposure and generated exploratory human systemic and tissue exposure predictions.

Omar Zaher, D. Selzer, H. Loer et al. · Archives of Toxicology · 0 citations