Author

C. Farquharson

2 papers indexed here

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Open access Sep 2026

Maintenance of bone health by osteoblasts in the absence of osteocytes: comparative analysis of gene expression in medaka and zebrafish vertebrae

Osteocytes are regarded as the strain-sensing bone cells; their capacity to sense and convert mechanical loads into biological signals underpins our current understanding of how bone is (re)modelled to normalise local strains. However, most extant fish are anosteocytic and lack osteocytes, yet their bone structure and...

S. Jayash, D. R. Dunbar, S. Guizard et al. · Bone Reports · 0 citations

#protein folding Open access Sep 2026

PHOSPHO1 deficiency delays osteogenic differentiation of osteoblasts, impairing mineralization and altering the protein composition of matrix vesicles.

It is indicated that cellular adaptation is insufficient to restore mineralization in the absence of PHOSPHO1, and instead, PHOSPHO1 appears to play a critical role in establishing the molecular and biophysical properties of MVs necessary for mineral nucleation and propagation.

L. H. S. Andrilli, L. Hayann, C. Tokuhara et al. · Bone · 0 citations