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C. Huttenhower

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Review Open access Oct 2026

Importance of faecal sample collection in prospective cohort studies to evaluate the effect of the gut microbiome on cancer development.

The gut microbiome has been linked to cancer in many cross-sectional studies. These studies compared individuals with and without cancer, but they do not establish causation. Prospective cohort studies, with faecal samples collected before a cancer diagnosis, will be instrumental in assessing the role of the gut microb...

E. Vogtmann, Caroline Y. Um, S. Zouiouich et al. · 0 citations
Review Aug 2026

Shaping the future of early-onset colorectal cancer prevention

This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.

Ruiyi Tian, Sina Azadnajafabad, E. Waters et al. · 0 citations
Open access Jul 2026

Comparative assessment of large language models for microbial phenotype assignment

This study systematically assessed the biological knowledge encoded in publicly available LLMs for structured phenotype assignment of microbial species, including state-of-the-art models such as Claude Sonnet 4 and the GPT-5 family of models.

Philipp C. Münch, Nasim Safaei, René Mreches et al. · 0 citations

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