Aug 2026· Nature Reviews. Cancer· Vol 26, pp. 830 - 848· 0 citations· 241 references
Medicine
TL;DR
This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.
This review critically synthesizes recent evidence on EOCRC epidemiology, risk architecture, life-course carcinogenesis, molecular and microbiome-associated mechanisms, diagnostic delay, screening limitations, treatment considerations, and survivorship needs, with the aim of reframing EOCRC as an age-attuned clinical a...
Magda Grześkiewicz-Szostak, K. Gęca, M. Skórzewska· Current Oncology Reports· 0 citations
Simple Summary Colorectal cancer diagnosed before age 50 is becoming more common in many countries, although the reasons remain uncertain. This review examined 75 publications on lifestyle, metabolic, clinical, medication-related, and social factors associated with early-onset disease. The clearest associations involve...
A. Alegre-Martínez, L. Cabañas-Alite, I. Fernández-Benet et al.· Cancers· 1 citation
Early‑onset colorectal cancer (EOCRC), defined as colorectal cancer (CRC) diagnosed before 50 years of age, is increasing globally. Colorectal cancer is currently the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide, with GLOBOCAN 2024 estimating approximately 2.04 mil...
A. Nogueira, Jennifer Brondon, Konstantin Haradinov et al.· Oncology and Therapy· 0 citations
The global EOPC burden among WCBA and its links to core metabolic determinants are delineated, providing an evidence base to guide targeted interventions in this priority population and support progress toward international development goals.
Jiaxing Li, Jing Luo, Qi-Hui Hu et al.· PLoS ONE· 0 citations
Early-onset cancers (EOCs), defined as cancers diagnosed before the age of 50, are increasing globally. This rise cannot be fully explained by improved detection, suggesting the involvement of evolving environmental and lifestyle-related risk factors. In parallel, the global prevalence of obesity has increased substant...
Mansi Upadhyay, Arianna V. Bastian, T. Cardaci et al.· Carcinogenesis· 0 citations
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, with its burden projected to rise. Screening average-risk individuals is recommended because several strategies reduced CRC incidence and mortality. While overall CRC incidence and mortality have stabilised or declined in many de...
K. Truninger, Hariharan Easwaran, Finlay A. Macrae et al.· Gut· 0 citations
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