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Open access Sep 2026

Microbiome alterations in mismatch-repair deficient metastatic colorectal cancer patients

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Many efforts have been made to stratify CRC cases, from investigating the genomic characteristics of the tumor to – more recently – considering the gut microbiome. Differences in the composition of the gut microbiome occur along...

Gianmarco Piccinno, Paolo Manghi, Luca Lazzari et al. · 0 citations
Review Aug 2026

Shaping the future of early-onset colorectal cancer prevention

This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.

Ruiyi Tian, Sina Azadnajafabad, E. Waters et al. · 0 citations

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