Author

C. Locatelli

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Open access Sep 2026

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Objectives Cell death and inflammatory pathways play important roles in adaptations to nutrient overload and metabolic dysfunction. This study investigates the metabolic consequences that arise from the dual disruption of both caspase 1 (Casp1) and receptor interacting protein kinase 3 (Ripk3) in mice fed a control or...

Madison D. Girouard, Conor O'Dwyer, C. Locatelli et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

MIR192 upregulates GLP-1 receptor and rescues statin-induced impairment of insulin secretion

Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential susceptibility to NOD and determine their effects on β-...

Yu-Lin Kuang, C. Locatelli, Yu-Qing Zhang et al. · Cardiovascular Diabetology · 0 citations