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Open access Sep 2026

Systematic Engineering of Loss-of-Function Alleles in the Zebrafish Mitochondrial Proteome

Pathogenic variants in the 13 protein-coding genes of the mitochondrial genome underlie clinically and biochemically heterogeneous disorders. Most mtDNA-encoded genes lack defined loss-of-function (LOF) models in vivo. To address this gap, we have generated Z-Terminator, a systematic in vivo atlas of loss-of-function a...

A. Sabharwal, Md Roushan Ali, Kyler S. Mitra et al. · 0 citations
#gene editing Open access Oct 2026

A naturally evolved mutation in cavefish mc3r reshapes energy homeostasis across development in a nutrient-limited environment

Food availability in natural habitats is often unpredictable and drives the selection of adaptive strategies in organisms to survive food scarcity. However, the genetic and molecular mechanisms that enable animals to survive under such nutritional extremes are poorly understood. Naturally adapted organisms therefore pr...

Tyler Guzman, Tathagata Biswas, V. Tiwari et al. · 0 citations

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