Review
Sep 2026
Pumping the brakes: immune checkpoints as regulators of immunity and targets of cancer therapy.
An overview of the immunologic mechanisms and clinical features of irAEs is provided, discussing how the CTLA-4 and PD-1/PD-L1 immune checkpoints help maintain immune balance, and how their blockade results in unchecked immune activation.
Musaab Alhezam, Michael T. Lam, Seigo Okada et al.
· Journal of Allergy and Clini... · 0 citations