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C. Smibert

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Open access Aug 2026

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

RNA splicing shapes neuronal identity and disease risk, yet current maps lack the developmental resolution and depth to resolve this complexity. Here, we integrate deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons to generate a high-resolution proteogenomic atlas of...

N. Xu, Katherine M. Rynard, E. Radley et al. · 1 citation
Open access Aug 2026

Pumilio and Brain tumor regulate the expression of Smaug during the Drosophila maternal-to-zygotic transition

A post-transcriptional regulatory pathway in which Pumilio and Brain tumor ensure orderly progression of the Drosophila maternal-to-zygotic transition by clearing smaug mRNA and preventing ectopic Smaug activity is defined.

A. Marsolais, Mariana Kekis, Harrison W Smith et al. · 0 citations

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