A post-transcriptional regulatory pathway in which Pumilio and Brain tumor ensure orderly progression of the Drosophila maternal-to-zygotic transition by clearing smaug mRNA and preventing ectopic Smaug activity is defined.
It is demonstrated that post-transcriptional regulation of the Profilin 2 (Pfn2) transcript is essential for differentiation of embryonic stem cells into the primary germ layer lineages and revealed the Pfn2 microRNA-IRE regulatory axis as a critical post-transcriptional regulatory node governing the switch from plurip...
Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh et al.· PLoS Genetics· 0 citations
It is demonstrated that TUG1, which is highly expressed in tumors, regulates early embryonic development in mice and is transformed from a cancer-specific effector to a critical regulator of the ZGA, raising the possibility that related regulatory principles may operate in other biological contexts.
Jian-Wu Wang, Guang Yang, Qingbo Yang et al.· Cellular and Molecular Life...· 0 citations
The link between decreased ZAR1/ZAR2 expression and abnormal epigenetic modifications in aged oocytes, as well as the relationship between human ZAR1 variants and oocyte maturation disorders and preimplantation embryonic developmental arrest, requires further validation through additional functional experiments and cli...
Jiao-Qi Mei, Bian-Ling Xu, Zhi Chen et al.· Journal of Ovarian Research· 0 citations
Ch Chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) uncovered PBX1 binding to a large number of different genomic sites in aNS cells, implicating PBX1 in neurogenic differentiation as well as broader biological functions.
It is suggested that miRNAs play a critical role in suppressing neuronal genes during the maturation of endocrine cells during the maturation of endocrine cells.
It is demonstrated that the RNA ac 4 C writer NAT10 is essential for the post-transcriptional regulation of mouse zygotic splicing activation and provide valuable view for further exploration of the epigenetic mechanism during maternal-to-zygotic transition.
Wen-Jing Wang, Yu-Ke Wu, Yun-Wen Wu et al.· Cell Death & Disease· 0 citations
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