TL;DR
It is suggested that miRNAs play a critical role in suppressing neuronal genes during the maturation of endocrine cells during the maturation of endocrine cells.
It is suggested that YY1 preserves B cell identity through coordinated regulation of transcriptional and post-transcriptional programs, with YY1-dependent miRNA networks contributing to the maintenance of B cell-associated gene expression and restriction of alternative lineage programs.
Temporal patterning is essential for generation of neuronal diversity in the developing vertebrate nervous system. A shared sequence of temporal transcription factors (tTFs) partitions neurons by birth date across much of the central nervous system. The molecular mechanisms that control the timing of expression of thes...
DOT1L is established as a barrier between these astrocyte states, limiting differentiation of the astrocytes expressing phagocytosis marker genes, and lowering the DOT1L-mediated epigenetic barrier strongly favours appearance of astrocytes with limited phagocytosis properties and reactivation of progenitor programs.
It is shown that knocking out Faf2 in neural progenitor cells results in increased ER stress signature at the protein and transcription level, indicating a conserved functional role in neural progenitor cells.
It is revealed that transcription of aak-1/AMPK is necessary to silence transcription in quiescent PGCs, and it is validated PGC transcription of aak-1/AMPK, and it is showed that zygotic aak-1/AMPK is required for PGC chromatin hyper-compaction, supporting reproductive success upon recovery.
The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how these various activities are regulated remains incompletely under...
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