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Author

Timothy R. Hughes

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Open access Aug 2026

An expanded codebook of human transcription factor DNA-binding specificity

A systematic effort to determine the sequence specificity of 332 putative and poorly characterized human TFs is described, which reveals tens of thousands of previously unknown, conserved and direct TF-binding sites across the human genome.

A. Jolma, Kaitlin U. Laverty, Ali Fathi et al. · 3 citations
Review Open access Aug 2026

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors

There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...

A. Jolma, A. Hernandez-Corchado, A. Yang et al. · 3 citations
Open access Aug 2026

Pumilio and Brain tumor regulate the expression of Smaug during the Drosophila maternal-to-zygotic transition

A post-transcriptional regulatory pathway in which Pumilio and Brain tumor ensure orderly progression of the Drosophila maternal-to-zygotic transition by clearing smaug mRNA and preventing ectopic Smaug activity is defined.

A. Marsolais, Mariana Kekis, Harrison W Smith et al. · 0 citations

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