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C. V. Robinson

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Open access Aug 2026

Structure of NHE6 and its lipid-mediated interactions regulating endosomal pH

Sodium-proton exchangers (NHEs) are found in all cells to regulate intracellular pH, sodium levels and cell volume. In humans, there are nine different NHE transporters (SLC9A1-9), which vary in tissue distribution, kinetics and regulation. NHE6 localizes to endosomal membranes and mutations in the protein are known to...

Suk-Han Jung, Hyunku Yeo, Hang Li et al. · 0 citations
Open access Aug 2026

Differential lipid selectivity of StARD phospholipid transporters revealed by native MS

Intracellular lipid transport in eukaryotes is largely mediated by lipid transfer proteins (LTPs). Transport kinetics differ markedly among lipid species, implying selective lipid recognition by the involved proteins. Here, we characterize endogenous ligands of the human phospholipid transporters STARD2, STARD7, and...

Carla Kirschbaum, Sophie A. S. Lawrence, Jack L. Bennett et al. · 0 citations

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