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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Catarina Brito

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Open access Sep 2026

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

ABSTRACT Gene therapies using adeno‐associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human‐induced pluripotent stem cell (hiPSC)‐derived innate immunocompetent 3D CNS model that reca...

C. M. Gomes, Gabriela Silva, Mafalda Aleixo et al. · 0 citations
#gene editing Open access Oct 2026

CRISPR–Cas9 Editing of Myeloid Lectins Reveals Target-Dependent Transcriptional Remodeling in Tumor-Associated Macrophages

Tumor-associated macrophages (TAMs) integrate multiple microenvironmental signals, including lectin-mediated recognition of tumor-associated glycans. Although several myeloid lectins have been implicated in tumor–macrophage interactions, their contributions to immunosuppressive TAM phenotypes remain poorly defined. We...

Gonçalo Trindade, M. Pinto, G. Domenici et al. · 0 citations
Review Open access Sep 2026

Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression

This review integrates evidence from tumor glycobiology, myeloid immunology, receptor signaling, experimental models, and therapeutic development to examine how C-type lectin receptors and Siglecs contribute to myeloid-mediated immune suppression.

Gonçalo Trindade, Angelina S. Palma, Catarina Brito · 2 citations

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