MRI derived biomarkers, particularly DTI-ALPS index and ePVSs analysis, demonstrate high potential as surrogate indicators of glymphatic impairment in AD, warranting harmonization of imaging protocols and longitudinal investigations to establish their translational utility in clinical biomarker frameworks.
Caterina Bernetti, R. Calandrelli, Fabio Pilato et al.· Neuroradiology· 0 citations
BackgroundAmyloid-targeting therapies (ATTs) such as donanemab may change the management of Alzheimer's disease (AD). However, ATTs require meticulous eligibility assessment to optimize the benefit-to-risk ratio.ObjectiveTo quantify the proportion of patients eligible for donanemab in a real-world Italian memory clinic...
F. Motolese, F. Ursini, D. Norata et al.· Journal of Alzheimer's Disea...· 0 citations
7T MRI robustly improves CMB detection in CAA and provides higher inter-rater reliability for vCMB classification than 3T, but weak cross-scanner correlation and agreement for the vCMB-to-total ratio preclude interchangeability across field strengths.
D. Botta, Caterina Bernetti, Jose Federico Ojeda Esparza et al.· AJNR. American journal of ne...· 0 citations
Current limitations of standardisation, reproducibility, and external validation that remain prerequisites before quantitative VCID imaging achieves formal regulatory biomarker qualification are outlined.
Jose Federico Ojeda-Esparza, D. Botta, A. Fitsiori et al.· British Journal of Radiology· 0 citations
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