Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review.

Glymphatic system alterations in schizophrenia evaluated by the DTI-ALPS index: A systematic review and meta-analysis.

BACKGROUND The glymphatic system has been extensively implicated in neurodegenerative diseases as a key pathway responsible for cerebral metabolic waste clearance. However, its role in schizophrenia remains poorly understood. This study aimed to evaluate glymphatic system function in patients with schizophrenia through...

Transdiagnostic Reductions in Glymphatic-Related Perivascular Diffusion Across Psychiatric Disorders: A Systematic Review and Meta-analysis.

BACKGROUND The glymphatic system, a perivascular pathway supporting cerebrospinal and interstitial fluid exchange and clearance, has been implicated in neurodegenerative and psychiatric disorders. Diffusion tensor imaging along the perivascular space (DTI-ALPS) provides a non-invasive proxy for glymphatic-related proce...

Imaging the glymphatic system in Huntington's disease: The benefits of a multimodal approach and clinical implications.

Targeting glymphatic-associated pathways for Alzheimer’s disease: a review of non-invasive modulation strategies, mechanisms, and emerging evidence

The glymphatic system, a cerebral waste clearance pathway identified over a decade ago, has reshaped understanding of Alzheimer’s disease (AD) pathogenesis by linking impaired brain homeostasis to amyloid-β and tau accumulation. This review synthesizes the biological mechanisms governing glymphatic function, including...

Glymphatic system dysfunction in central nervous system malignancies: A narrative review

All available preclinical and clinical evidence on glymphatic dynamics in CNS malignancies and their implications in the glymphatic system function is synthesized.

Investigating the DTI-ALPS index and its association with cognitive impairment in Alzheimer’s disease: a diffusion tensor imaging study

Objectives With the global aging population, Alzheimer’s disease (AD) poses a major health challenge. The diffusion tensor image (DTI) analysis along the perivascular space (DTI-ALPS) index has emerged as a noninvasive imaging marker that indirectly reflects glymphatic function. However, its alterations in AD and their...