Oct 2026
Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial.
Maclean C. Sellars, Jessica A. Frank, Bohoon Shim et al.
· Nature Medicine · 0 citations
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Sep 2026
Spatially confined IL-12 programs CAR-NK through mTORC1 to coordinate antitumor immune networks.
Solid tumors evade immunotherapy because of immunosuppressive microenvironments that limit immune cell persistence and function. Although interleukin-12 (IL-12) potently activates antitumor immunity, its clinical use has been constrained by systemic toxicity. Here we engineered a CAR natural killer (NK) cell platform t...
Mubin Tarannum, K. Dinh, Mila Stanojevic et al.
· Cancer Discovery · 0 citations
Jul 2026
Tertiary lymphoid structures harbour stem-like tumour-specific T cells
Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.
Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al.
· Nature · 2 citations