Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Integrative single cell analysis of CD8+ T-cells across early and advanced oral cancers reveals signatures of anti-tumour activity

This work establishes a generalizable framework for mapping tumour-engaged immunity without knowledge of the underlying antigen in the transcriptome by demonstrating that clonal behaviour across space and time encodes tumour reactivity in the transcriptome.

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved Survival

This represents one of the first spatially resolved analyses of TLS-like immune architecture in SCLC, demonstrating that organized lymphoid immunity can emerge in this classically immune-evasive disease and is associated with improved survival.

46 Anti-tumour immune responses in melanoma brain metastases require cDC1 population and the extracranial tumour

It is hypothesize that extracranial tumour inhibits intracranial tumour growth through extracranial cDC1-mediated priming and expansion of CD8+ T cells which then home to intracranial tumours, by directly enhancing the activation of intracranial cDC1s, or a combination of both.

Clinical impact and therapeutic potential of tertiary lymphoid structures in melanoma

By promoting TLS formation to amplify intratumoral immune responses, these approaches hold promise for overcoming resistance to immunotherapy and improving outcomes in advanced melanoma and other malignancies.

Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization.

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

In-depth spatial profiling identifies PLA2G2D as a TDLN-centred targetable immune checkpoint for cancer immunotherapy and identifies a specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes that is associated with poor prognosis in patients.