Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Here we integrate high-resolution spatial transcriptomics and evolving lineage-tracing technologies to elucidate how tumor expansion, plasticity and metastasis co-evolve with microenvironmental remodeling in...
Matthew G. Jones, Da-Wei Sun, Kyung Hoi (Joseph) Min et al.· Nature Genetics· 0 citations
A major challenge in genomics is deciphering the functional consequences of non-coding genetic variation. Here we present AlphaGenome Atlas, a comprehensive resource that enables the joint interpretation and prioritization of variant effects across the entire human genome. Using AlphaGenome, we predicted the regulatory...
Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen et al.· medRxiv· 3 citations· ⚡1
TissueFormer is introduced, a framework for pretraining foundation models with linear rather than quadratic computational complexity, overcoming a long-standing barrier to modeling long-range dependencies at scale.
Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.
Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al.· Nature· 2 citations
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