Abstract Background We sought to map the immunological landscape of metastatic renal cell carcinoma (RCC) in order to understand the mechanisms that dictate response to immune checkpoint inhibitors (ICI) and uncover biomarkers for ICI response. Methods We generated a single-cell RNA sequencing (scRNA-seq) atlas of the...
Ethan C. Burns, S. Kashima, Rishabh Rout et al.· The Oncologist· 0 citations
Renal cell carcinomas (RCC) comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes and chromatin accessibility profile...
Prathyusha Konda, Alexandra J. Wakolbinger, Yan-Tong Cui et al.· Nature Communications· 0 citations
A tissue residency gene program in Tex cells associated with non-response to immunotherapy was identified and nominates resident memory exhausted CD8+ T cells as a targetable subset of cells to improve CD8+ T cell-mediated anti-tumor immunity.
Rishabh Rout, S. Kashima, M. Hugaboom et al.· The Oncologist· 0 citations
Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.
Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al.· Nature· 2 citations
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