Aug 2026
Tc17-driven antibody-independent mucosal immunity is critical for protection against extracellular bacterial pneumonia
It is shown that protective immunity conferred by mucosal mRNA vaccines (but not parenteral) require neither serum IgG nor airway secretory IgA, but instead depends on a previously unrecognized lung-resident CD8⁺IL-17⁺ T-cells (Tc17) that rapidly recruits neutrophils/macrophages to eliminate bacteria.
Yuheng Liu, Jingjing Zhang, Zhi-Fu Chen et al.
· bioRxiv · 0 citations