It is shown that protective immunity conferred by mucosal mRNA vaccines (but not parenteral) require neither serum IgG nor airway secretory IgA, but instead depends on a previously unrecognized lung-resident CD8⁺IL-17⁺ T-cells (Tc17) that rapidly recruits neutrophils/macrophages to eliminate bacteria.
Conventional respiratory vaccines protect through antigen-specific immunity, leaving broad gaps against antigenically diverse and emerging pathogens and inducing little protection at the airway surface itself. Trained immunity, the durable epigenetic and metabolic reprogramming of innate immune cells and their bone mar...
The identification of a multi-antigen vaccine candidate, Ad-8CPR2, as the most immunogenic construct, which incorporates M. tuberculosis antigenic proteins with strong immunogenicity and functional properties, which are fused with peptide segments capable of augmenting antigen-specific immune responses.
Li-Qun Wei, Peng Wang, Ying Li et al.· Microbiology spectrum· 0 citations
These findings revealed that incorporating HKCC significantly increased cellular responses and mucosal IgA and systemic IgG titres in pre- and post-exposure models, respectively, and correlated with reduced mycobacterial burden in the lungs, spleens, and livers and with improved lung pathology.
Shanika Werellagama, Nancy Gupta, Jie Li et al.· Emerging Microbes and Infect...· 0 citations
Rapid development of host immunity is critical during the emergence of viral outbreaks when vaccines are not yet available. Here, we demonstrate that CpG oligodeoxynucleotide-schizophyllan complex (K3-SPG) induces antigen-independent, long-term protection against lethal respiratory virus infection. A single intranasal...
Asuka Joy Tobuse, K. Kobiyama, Jun Tsuchida et al.· Science Advances· 0 citations
Respiratory infections remain a relevant global health concern nowadays. The rapid dissemination and high mutational ratio of some pathogens, amid human demographic drivers, increases their pandemic potential. On the other hand, some bacterial infections have re-emerged with new resistant variants, supporting the need...
Rong Chen, Chang-Zan Tan, Wen Li et al.· bioRxiv· 0 citations
ABSTRACT Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are ESKAPE pathogens that are responsible for severe skin and soft tissue infections (SSTIs), particularly in the elderly and those with immunocompromising conditions. Rising rates of methicillin-resistant S. aureus (MRSA) and carbapenem-resistant PA h...
Suhrid Maiti, T. Lu, Zackary Dietz et al.· Infection and Immunity· 0 citations
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