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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhi-Fu Chen

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2 papers indexed here

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Aug 2026

Tc17-driven antibody-independent mucosal immunity is critical for protection against extracellular bacterial pneumonia

It is shown that protective immunity conferred by mucosal mRNA vaccines (but not parenteral) require neither serum IgG nor airway secretory IgA, but instead depends on a previously unrecognized lung-resident CD8⁺IL-17⁺ T-cells (Tc17) that rapidly recruits neutrophils/macrophages to eliminate bacteria.

Yuheng Liu, Jingjing Zhang, Zhi-Fu Chen et al. · 0 citations
Aug 2026

Rational N-Terminal Tuning of Bacitracin A: Repurposing a Classic Antibiotic to Combat Multidrug-Resistant Gram-Positive Pathogens.

A site-selective semisynthetic modification strategy via reductive amination of bacitracin A's N-terminal primary amine is established, providing a rational strategy for bacitracin optimization and highlighting the potential of N-terminal modification for developing improved antibacterial agents.

Si-Jie Cheng, Jing-Wen Liao, Xin-Ru Xia et al. · 0 citations

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