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Chao-Ping Hu

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#gene editing Review Open access Sep 2026

Current and emerging therapeutic strategies for mitochondrial disorders

This review examines the literature over the past decades on mitochondrial disease treatments, including traditional Cocktail therapy, target therapy, multidisciplinary management, gene therapy, mtDNA base editing, and mitochondrial replacement therapy.

Chao-Ping Hu, Xiao-Lei Wang, Fang-Hao Fang et al. · 0 citations
Review Open access Jul 2026

Comprehensive Mapping of SGCA Variant Effects Reveals Domain-Specific Constraints Relevant to Sarcoglycanopathies

A comprehensive functional atlas is generated that distinguishes tolerated and damaging variants, aligning with independent genetic and clinical evidence, and reveals domain-specific properties of the cytoplasmic region, in which C-terminal truncating variants retain membrane localization, suggesting possible pathogeni...

Shushu Huang, Kenneth K. Ng, Yan-Yu Lu et al. · 0 citations

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