Cheng-Qian Yuan

Functional abiotic metabolite assembly hypothesis for the early events in the origin of life

The RNA world hypothesis provides a compelling framework for the emergence of life, yet a fundamental gap remains between simple abiotic molecules and complex functional RNA polymers. Here, we propose the Functional Abiotic Metabolite Assembly hypothesis, in which simple prebiotically abundant molecules, particularly a...

Correction to "Mapping Free-Energy Landscapes to Decipher Amphiphilic Peptide Multistep Self-Assembly".

In Silicon Deciphering Atomic-Scale Structural Units in Peptide Glass.

Peptide glasses are an emerging class of biofunctional amorphous materials, but their atomic-level structure has remained elusive. Here, we resolve the three-dimensional (3D) organization of peptide glasses using a cyclic dipeptide model, combining molecular dynamics simulations with 2D solid-state NMR fingerprinting....

Mapping Free-Energy Landscapes to Decipher Amphiphilic Peptide Multistep Self-Assembly.

The formation of fibrous architectures via peptide self-assembly underpins numerous biological functions and biomaterial applications; however, the thermodynamic origins of multistep assembly pathways remain elusive. Here, we map the complete free-energy landscape governing the liquid-liquid phase separation (LLPS)-med...