Author

Chinmai Pindi

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#gene editing Open access Oct 2026

Visualizing the Atomic-Level Impact of Anti-CRISPR II–C1 Inhibition on Geo Cas9 with Integrated Structural Biophysics

Abstract Anti-CRISPRs (Acrs) are small protein inhibitors of CRISPR-Cas effectors that originate from the translated genetic material of bacteriophage. Harnessing the natural ability of Acrs to bind and disrupt CRISPR-Cas editing can provide enhanced spatiotemporal control of gene editing. Recent studies have revealed...

Alexa L Knight, Helen B Belato, Praise Lasekan et al. · JACS Au · 0 citations

#gene editing Open access Oct 2026

Transposon end recognition and pairing by I-F3 CRISPR-associated transposase

To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon 7 (Tn7)–like transposons typically contain asymmetric left- and right-end sequences that flank and define DNA cargo. However, how the tra...

Vinh H. Truong, Darcie J. Miller, Shirin Fatma et al. · Science Advances · 0 citations