Enhanced Anti-inflammatory Effects of 18β-Glycyrrhetinic Acid and Hesperetin for the Treatment of Psoriasis: Evidence from LPS-stimulated RAW264.7 Cells and Imiquimod-induced Psoriasis Mouse Model.
The results demonstrated that GA and HST synergistically inhibited nitric oxide production at a 1:1 concentration ratio in vitro and significantly reduced the PASI scores, spleen index, Baker's histology score, and pro-inflammatory cytokines IL-1β, IL-6, IL-17, IL-22, IL-23, and TNF-α in the IMQ-induced psoriasis mouse...