This paper comprehensively analyzes core approaches, including metabolic pathway reconstruction, cofactor engineering, and the optimization of industrial chassis cells, to overcome significant enzymatic bottlenecks and carbon flux imbalances and provides a comprehensive blueprint for developing next-generation, cost-ef...
Yue-Fan Zhang, Yan Zhang, Shu-Yan Xia et al.· 3 Biotech· 0 citations
This Review systematically examines synthetic biology-driven strategies for improving sclareol production, with particular emphasis on microbial chassis engineering, metabolic pathway optimization, and enzyme engineering.
Yi-Wen Yu, Long-Qing Wang, Yan Zhang et al.· ACS Omega· 0 citations
This review frames cellulosome engineering as a process-aware macromolecular assembly problem, in which catalytic balance, substrate targeting, assembly size, inter-domain spacing, and environmental robustness must be optimized together.
Menglan Liao, Zi-Xuan Wan, Long-Qing Wang et al.· International Journal of Bio...· 0 citations
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