This paper comprehensively analyzes core approaches, including metabolic pathway reconstruction, cofactor engineering, and the optimization of industrial chassis cells, to overcome significant enzymatic bottlenecks and carbon flux imbalances and provides a comprehensive blueprint for developing next-generation, cost-effective microbial cell factories.
2-Phenylethanol (2-PE) is a valuable aromatic alcohol known for its rose-like scent, widely used in the fragrance, food, and cosmetics industries. The growing demand for “natural” certified products is driving increasing interest in microbial fermentation as a sustainable and promising alternative to chemical synthesis...
Yi-Bo Ning, Chang-Tong Lu, Qing-Fu Wang et al.· Frontiers in Microbiology· 0 citations
Tryptophan-derived metabolites are indole-containing compounds with applications in medicine, functional foods, and agriculture. Conventional production via plant extraction or chemical synthesis is often inefficient and unsustainable, prompting the development of microbial biosynthesis. In this review, these metabolit...
Chen-Xi Qiu, Hong-Wei Guo, Quan-Pu Ren et al.· Journal of Agricultural and...· 0 citations
This thesis advances Yarrowia lipolytica as a more versatile platform for biomanufacturing. We demonstrated robust growth and lipid production in pretreated lignocellulosic hydrolysates, supporting the use of low-cost renewable feedstocks. We then identified key constraints in xylose utilization and developed strategie...
Key synergistic mechanisms, including in situ detoxification, parallel utilization of pentose and hexose mixtures, and metabolite exchange (cross-feeding), which distribute metabolic functions among specialized strains, expanding metabolic diversity and optimizing carbon valorization, are analyzed.
W. Monroy-Martínez, J. C. González-Hernández, M. C. Chávez-Parga· World Journal of Microbiolog...· 0 citations
This review critically evaluates recent advances in microbial kojic acid production with an emphasis on biosynthetic regulation, fermentation technologies, strain engineering, downstream processing, and sustainable bioprocessing strategies and highlights emerging industrial applications of kojic acid and its derivative...
Parth Shroff, Darshan Marjadi· Journal of Advances in Biolo...· 0 citations
Kluyveromyces marxianus is an emerging microbial cell factory characterized by rapid growth, strong thermo- and acid-tolerance, and broad substrate utilization, including second-generation feedstocks. Combined with substantial intraspecific genetic diversity and recent advances in genetic engineering tools, these trait...
Jolien Smets, Karin Voordeckers, Jan Steensels et al.· Trends in Biotechnology· 0 citations
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